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Studies (105, 106) have found that GE also has a role in preventing angiogenesis in RA, which is related to the up-regulation of the expression of phosphate and tension homelessness deleted on chromoten (PTEN) to inhibit PI3K/Akt signal activation, the restoration of dynamic balance of pro/anti-angiogenic factors in vascular endothelial cells (VEC), and the reduction of FLSs stimulation to VEC by inhibiting the VEGF/SPK1/S1P pathway

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Sin embargo, histopatolgicamente ests mculas melanticas se distinguen fcilmente del melanoma in situ, porque no se observa incremento en el nmero de melanocitos o este aumento es muy discreto