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Research also suggests that high homocysteine levels may affect the blood-brain barrier, contribute to the build-ups of amyloid plaques (in Alzheimers disease), reduce bone density, impair correct functioning of insulin and even promote cancer cell division (Kumar et al., 2017)
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Specifically, in the morphine-induced constipation model mice, we demonstrate that morphine inhibits PVN Glu neuronal activity through MOR, thereby reducing DMV Ach neuronal activity, which leads to decreased small intestinal motility and a reduced transit rate, ultimately manifesting in constipation
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