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In one study, immortalized HUVECs were treated with chloroquine, a lysosomal inhibitor, which reduced the activity of -Gal A to a level of 20% of the control and resulted in the formation of intracellular inclusions typical for the Fabry disease phenotype [59]

Reports that DPP-4 may be associated with glucagon in the secretory granules of the pancreatic -cell first emerged in 1993, when positive staining in pig islets was shown using immunohistochemical and enzyme histochemical techniques (96), but the pancreatic localization of DPP-4 has also been unequivocally demonstrated more recently using molecular biological techniques (9799)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Pavlidis P, Tsakmaki A, Pantazi E, Li K, Cozzetto D, Digby-Bell J, et al