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The goal is to pool the liquid directly over the sublingual mucosa, the tissue on the floor of your mouth beneath the tongue

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

Pillar 6: Pioglitazone (PPAR-gamma agonist) Pioglitazone can improve insulin sensitivity partly by redistributing fat away from ectopic depots (liver and muscle) towards safer subcutaneous stores