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In addition, tumor necrosis factor (TNF) binding to TNFRSF1B activates TRAF2/MAPK signaling, enhances TRPV1 and SCN10A expression, and thereby facilitates NPP development in sequence ( 8 Cellular basis of synaptic plasticity mediated by activated non-neuronal cells 8.1 Pro-inflammatory cytokines Pro-inflammatory cytokines (PICs), such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor - (TNF-), have been reported to be positively associated with NPP

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Signals from dural perivascular neurons instigate a sequence of events that lead to the release of inflammatory mediators, sterile meningeal inflammation, and sensitization of pain-processing brain regions (33)

Quantitative data were expressed as the mean standard deviation (SD)