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Cardiovascular and Kidney Outcomes No dedicated prospective RCT has yet been powered to compare combined SGLT2i and GLP-1RA therapy versus monotherapy for cardiovascular and kidney endpoints, although the ongoing PRECIDENTD trial is expected to address this gap [36]

Best fit for: People with fatty liver disease (MAFLD/MASH) Asian populations with high visceral fat at lower BMI levels Individuals who need stronger effects on energy expenditure , not just appetite Patients located in China (only approved market so far) Those who did not respond well to GIP/GLP-1 drugs like tirzepatide How Do These Compare to Semaglutide, Retatrutide & Other Agents

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The process starts with an in-depth medical evaluation