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In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization

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Pancreatitis and gallbladder issues: Severe abdominal pain that radiates to the back, nausea, fever, or vomiting while using GLP-1s may indicate inflammation of the pancreas, while upper right abdominal pain, jaundice, fever, and nausea can be due to gallbladder issues such as gallstones