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Frsth, P

We found significant decrease in DNA polymerase kappa (POLK) (log2 fold = 2.987, P = 0.026), CD109 molecule (CD109) (log2 fold = 3.977, P = 0.027), cathelicidin antimicrobial peptide (CAMP) (log2 fold = 5.020, P = 0.012), nucleolar protein interacting with the FHA domain of MKI67 (NIFK) (log2 fold = 5.048, P = 0.019) and serglycin (SRGN) (log2 fold = 6.286, P = 0.009) GP levels compared with the levels before 4-week intermittent fasting

Obese Ningxiang pig-derived microbiota rewires carnitine metabolism to promote muscle fatty acid deposition in lean DLY pigs

Cagrilintide also has one of the lowest GI odds ratios among the incretin and amylin compound class in a 2025 Bayesian network meta-analysis of multi-target obesity therapies the relevance for the stack is that adding cagrilintide to retatrutide may not compound GI burden as severely as adding a second GLP-1 agonist would