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Sleep onset time shortens, and the quality of early-night deep sleep improves because youre entering sleep in a calmer neurological state rather than a stressed one

This is particularly noteworthy because two competing oral small-molecule GLP-1 programs from Pfizer, lotiglipron (discontinued in 2023) and danuglipron (discontinued in April 2025), were terminated due to liver toxicity concerns

This process can reduce the appearance of dark spots and enhance overall skin brightness

2ad), suggesting that the combination of RSL3 treatment and LDHB silencing results in increased levels of lipid hydroperoxides that reduce colony formation and survival