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Although the metabolites released from hepatocytes after drug exposure and injury are only a part of the altered endometabolome, they can still serve as potential biomarkers for hepatotoxicity in vivo DILI studies, as recent research has demonstrated (Quints et al., 2021)

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Add to this the fact that some depigmenting ingredients affect not only dark spots but also the skin around them, and it becomes clear that it's not always easy to find the best dark spot serums to minimize dark spots and hyperpigmentation on dark skin

Some results are usually seen within 24 hours, with complete results 2-3 weeks post treatment