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Helper or cytotoxic T cells secrete factors such as interferon- (IFN-) and IL-17 that compromise cartilage integrity ( Although dendritic cells (DCs) and natural killer (NK) cells are less abundant in OA synovium compared with macrophages and T cells, they can still influence synovitis severity and iron homeostasis by secreting inflammatory mediators or cooperating with T cells

For example, Uar Bernard, a defensive tackle for the Philadelphia Eagles, is 64, weighs 306 pounds, and would be considered obese with a BMI of 37.2, yet he only has 6% body fat

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32 ANTICONVULSANTS Pregabalin and gabapentin are first-line treatment options for diabetic peripheral neuropathy, with pregabalin being slightly preferred