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When appetite vanishes, some patients eat fewer than 500 to 800 calories per day

10.1039/C9FO01178A 24 ChengD.ChangH.MaS.GuoJ.SheG.ZhangF.et al (2018)

However, certain populations are at higher risk of deficiency: Adults over 50 (reduced absorption capacity) Individuals following vegan or strict vegetarian diets Those with gastrointestinal conditions such as Crohns disease or celiac disease Individuals taking long-term acid-reducing medications (PPIs, H blockers) When oral supplementation is insufficient or absorption is compromised, vitamin B12 shots deliver the nutrient directly into the bloodstream, bypassing the digestive system entirely