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Stress excitatory signals from the NTS are conveyed via ascending catecholaminergic (noradrenergic and adrenergic) projections to the PVN [15, 17, 32], as lesions of these projection neurons reduce HPA axis responses to systemic stressors [33, 34]

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However in type 2 diabetes, B cell glucose metabolism is dysfunctional, resulting in elevated blood glucose levels

Clinical trials have shown that tirzepatide can help people lose 1522% of their body weight when combined with healthy lifestyle changes results that were previously only seen with bariatric surgery