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Liver injury in NAFLD is caused by two mechanisms in general: (1) by peripheral resistance to insulin, and (2) by intrahepatic oxidative stress, whether with an increase of reactive oxygen species and reactive nitrogen species (ROS and RNS) and/or as a result of the decrease in antioxidant tissue levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Karuppagounder S.S., Alin L., Chen Y., Brand D., Bourassa M.W., Dietrich K., Wilkinson C.M., Nadeau C.A., Kumar A., Perry S., et al