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IL-4/IL-13 signaling pathway The receptors of allergic cytokines, including IL-4, IL-5, IL-13, IL-31, and thymic stromal lymphopoietin (TSLP), trigger the JAK/STAT pathway

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D2, encoded by DIO2 gene, is primarily expressed in the thyroid, brain, anterior pituitary and brown adipose tissue, where contributes local conversion of T4 in T3

Second, the C20 fatty di-acid moiety attached via a Glu2AEEA linker at Lys-20 enables reversible albumin binding, dramatically extending the serum half-life to approximately five days