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During the pivotal clinical trials for tirzepatide, musculoskeletal symptoms including back pain (reported in 4-7% of participants) and arthralgia (3-5%) were documented, but these occurred at frequencies similar to placebo groups in most studies according to the European Medicines Agency's European Public Assessment Report (EPAR)

These drugs mimic a natural hormone in the body called glucagon-like peptide-1 (GLP-1) , which plays an important role in digestion, blood sugar regulation, and appetite control

Problemas renales: Disminucin significativa en la cantidad de orina Hinchazn de piernas, tobillos o pies Fatiga extrema o confusin La deshidratacin por vmitos o diarrea persistentes puede afectar la funcin renal, especialmente en pacientes con enfermedad renal preexistente

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