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and insulin or insulin analog use was 45.4% and 45.0%, respectively

Journal of pharmaceutical sciences, 71 (3), 282-285

12 As this confers a much longer half-life than that of native sequence GLP-1 (hours rather than minutes), the development of GLP-1 RAs has proceeded down two paths: as analogues of either human GLP-1, or of exendin-4