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In the presence of continued oxidative stress, DHA undergoes irreversible degradation to diketogulonic acid which is implicated in the modification and crosslinking of lens proteins [69] (Figure 3)

This systemic vasoconstriction can be clinically observed in preeclampsia and acts as a major indicator of pregnancy complications

From a clinical perspective, these findings underscore the value of exploring interventions that modulate and support oxidative stress pathwaysparticularly those relative to glutathione synthesis or recyclingas adjunctive strategies for managing treatment-resistant depression

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