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Boehringer Ingelheim's survodutide, a GLP-1/glucagon dual agonist without the GIP component, is a different shape of bet on the same hypothesis: that going beyond pure GLP-1 is where the next decade of obesity pharmacology lives

We still require controlled human trials, standardized dosing, and long-term safety studies

(Long-term cardiovascular outcomes trial that does not gate initial obesity approval but informs any later cardiovascular indication.) Jastreboff AM, Kaplan LM, Frias JP, et al

Glutathione deficiency contributes to oxidative stress, which can accelerate aging and the development of age-related disorders