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Court data shows thousands of cases overall focused primarily on GI injuries (e.g., gastroparesis in ~75% of sampled claims) and vision loss (at least 110 plaintiffs), with thyroid concerns tied to a boxed warning from rodent studies

Results vary based on starting weight, diet, and adherence to protocol

Variants in genes affecting serotonin signaling, dopamine receptors, and inflammatory pathways can influence both antibiotic tolerance and semaglutide side effects

In response to global concerns, the 2025 ADA Standards of Care emphasize reducing global health disparities in diabetes care, particularly in low-resource settings [32]