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+ We do not treat patients who are pregnant or breastfeeding, who have a known allergy to any component of the formulation including pineapple-derived bromelain, who have an active skin infection in the treatment area, who have a bleeding disorder or are on certain blood-thinning medications, who have significant liver, kidney or heart disease, or who have a history of keloid scarring

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Clinical trials using dietary supplements of bioactive peptides have shown improvements in GFR and proteinuria, underscoring their potential as adjuvant therapies in managing CKD [67]

Comment Hepatocellular hypertrophy, secondary to increase in microsomal enzymes often occurs with a zonal or specific lobular pattern and commonly occurs following exposure to enzyme inducing xenobiotics