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8 Remaining Questions and Knowledge Gaps There is strong evidence that synovitis drives worse outcomes in osteoarthritis, contributing to more severe and persistent pain, heightened pain sensitization, faster structural deterioration, and an increased need for joint replacement

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Emerging data suggest that semaglutides benefits regarding cardiometabolic and renal outcomes may be independent ofor only minimally mediated byglycemic control and weight loss

Notably, CHOP is primarily expressed by myeloid cells infiltrating the tumor microenvironment, excluding macrophages [60]