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Each one tells you something different: Serum B12 Whats floating around in your blood Holotranscobalamin Whats actually available for your cells to use MMA Whether your cells are getting enough B12 to function normally Homocysteine Another marker of functional B12 status People who track multiple markers usually get better results with lower doses compared to those who only watch their B12 numbers

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1 H-NMR urine metabolomics, excluding TMA and dimethylamine, was the worst predictor explaining 1.5% of TMAO variance and correcting for urinary creatinine, computed by 1 H-NMR (Methods), did not improve predictions explaining 1% of TMAO variance on average (Supplementary Fig

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