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trial 2: N = 32) demonstrated that there were no clinically relevant effects of oral semaglutide (20 mg) on the plasma concentration-time curve (AUC) and maximum plasma concentration ( C max ) for the antihypertensive drug lisinopril (20 mg single dose [trial 1]), the anticoagulant agent warfarin (25 mg single dose [trial 1]), or digoxin (500 g [trial 2]) [42]
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SR4 was previously synthesized from a validated protocol at the Chemical GMP Synthesis Facility, Beckman Research Institute of the City of Hope (CA, USA) (14)
doi: 10.1111/dom.15410
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