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Interestingly, this residue is conserved in Class B1 GPCRs, such as glucagon, vasoactive intestinal peptide (VIP), and glucagon-like peptide-1 (GLP-1) (Liu et al., 2025)

The best antibody pairs for bispecific antibodies are commonly identified experimentally and the screening space grows quadratically with the number of antibody sequences to be tested in combination - in one study, 40,000 bispecific antibodies were examined 36