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Additionally, the semaglutide group had an 18% lower risk of MACE ( SGLT2 inhibitors have demonstrated significant renoprotective effects in patients with type 2 diabetes and CKD, reducing the risk of renal disease progression, the need for dialysis or kidney transplantation, and renal or cardiovascular mortality

are legally required to undergo rigorous safety and efficacy testing and must be approved by the FDA, the same rules do not apply to supplements

Some are also approved for a liver condition known as metabolic dysfunction-associated steatohepatitis (MASH)

Other patients experienced side effects such as redness, swelling, or pain at the injection site