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Medullary thyroid cancer history and MEN2 are firm contraindications GLP-1 medications, particularly semaglutide, are not recommended for these patients due to thyroid C-cell tumor risk

Tirzepatide (Dual Receptor) Mounjaro FDA-approved for type 2 diabetes Zepbound FDA-approved for obesity Tirzepatide activates two receptors: GLP-1 and GIP

1 # Includes abdominal pain, abdominal pain upper, abdominal pain lower, gastrointestinal pain, abdominal tenderness, abdominal discomfort, and epigastric discomfort

Common gastrointestinal side effects include nausea, early satiety, constipation, and reflux, manageable through smaller frequent meals and strategic food choices