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Intake of LCT and MCT is dependent on the specific type of lcFAOD, the residual enzyme activity, and age of the patient
Because cuproptosis preferentially targets cells with high oxidative phosphorylation (OXPHOS) dependency, whereas glycolytic tumors remain relatively resistant, it exposes a distinct metabolic vulnerability in cancer and presents unique therapeutic opportunities 165,166
In these cells, it inhibited HGF-induced cell migration and invasion, xenograft growth and metastasis in SCID mice
Future therapeutic strategies must rigorously evaluate extrahepatic safety, particularly cardiovascular and metabolic sequelae of chronic adrenergic modulation
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