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Peroxisome proliferator-activated receptor alpha (PPAR), a key nuclear transcription factor that regulates keratinocyte differentiation and epidermal lipid metabolism, is markedly downregulated in AD (Kuai et al., 2024), leading to impaired barrier integrity and defective lipid synthesis, which further supported by PPAR agonist-induced barrier restoration in ex vivo skin model (Majewski et al., 2021)

Orlistat (Xenical) generally costs between $150 and $300 per month, while phentermine (Adipex-P) is typically priced between $50 and $150 monthly

Body composition: 4 to 12 weeks

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