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Dietary alkali and bicarbonate therapy may improve bicarbonate status and may slow progression in selected patients, but treatment must account for sodium load, potassium, edema, blood pressure and medications

Erythrocyte folate concentrations provide an accurate measure of long-term folate intakes

AHK-Cu (Ala-His-Lys-Cu) is a related copper tripeptide found in human plasma that shares the His-Lys copper-binding motif but substitutes alanine for glycine at the N-terminal position, resulting in a slightly different copper coordination geometry and a distinct (though overlapping) gene expression modulation profile