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DNA damage response pathway regulates Nrf2 in response to oxidative stress

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Dose adjustment is not recommended in patients with mild-severe renal impairment (eGFR = 15-89 mL/min/1.73 m 2 ), but use is not recommended for patients with end-stage renal disease (127)

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It is the only form of vitamin B12, medically known as cobalamin, that is naturally supported by the human body

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