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Am J Physiol Endocrinol Metab 305(11):E1367E1374 Dickson SL et al (2012) The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors

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Specific ECM-based biomarkers indicative of MMP-2 activity, such as C1M (MMP-2, 9, 13 mediated degradation of type I collagen) and C4M (MMP-2, 9, 12 mediated degradation of type IV collagen), are significantly elevated in higher Hurley stages (II and III) of HS and show a moderate-strong correlation with the Hidradenitis Suppurativa Score (HSS), a classification system of the disease severity, reflecting ongoing dermis degradation and disease activity [104, 105] (Table 1, Fig