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Social media platforms and other digital platforms, using generic hashtags, have contributed to the widespread promotion of melanotan products, despite the presence of case reports documenting serious side effects

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Previous investigations have demonstrated multiple genomic and non-genomic alterations rendering intrinsic resistance, including loss of PTEN , loss of NF1 , CCND1 amplification, COT upregulation, RAC1 mutation, eIF4F activation, low MITF expression, and high AXL expression

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