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However, its metabolism places a significant burden on the livers detoxification and antioxidant systems , particularly through depletion of glutathione

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However, the detailed mechanism by which brusatol enhances Nrf2 degradation and how it selectively inhibits the Keap1Nrf2 pathway warrants further investigation

The interconversion stage of the pentose phosphate pathway In cells with active nucleic acid synthesis, ribulose-5-phosphate from the 6-phosphoglucose dehydrogenase reaction is isomerized to ribose-5-phosphate for synthesis of ribo- and deoxyribonucleotides for RNA and DNA ( Fig