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As potential inducer of HEP expression, phytoestrogens are promising dietary supplements to reduce iron overload and prevent any sequelae of iron-induced toxicities such as hyperferritinemia, coagulopathies and/or thromboembolism, which are prominent clinical manifestations in COVID-19 and PASC 94,144,494,495

It also activates key longevity pathways, including sirtuins and PARPs, which are involved in DNA repair and cellular resilience (Verdin, 2015)

Potential adverse effects such as weight gain [147], dyslipidemia, and increased risk of cerebrovascular and cardiovascular morbidity [148] are significant concerns

In BD patients, a butyrate-rich diet was also observed to modulate blood redox status and enhance fibrinolysis