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1) A set of well identified inflammatory biomarkers (IL-6, TNF-, IL-1, IFN-, neutrophil and NET biomarkers) 2) Additional biomarkers including the awakening cortisol response, zonulin, tryptophan, kynurenine 3) Key quantified questionnaire-based symptoms (fatigue, ability to concentrate and to memorize) and number of symptoms 4) Functional tests including HRV, VO 2max , orthostatic intolerance and cognitive tests

It has been reported 289 that PARP1 suppresses tumor initiation after DNA alkylation but also promotes tumor progression driven by inflammation

The lack of universal NPS assessments is also an obstacle, translating into ambiguous standards of data validity

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