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Arrange a routine appointment if: Digestive side effects persist beyond 12 weeks without improvement Symptoms significantly impact your quality of life or ability to maintain adequate nutrition You're unable to tolerate the dose escalation schedule You experience unexplained weight loss beyond expected therapeutic effects New or worsening symptoms develop after the initial adjustment period Consider discontinuation and medical review if gastrointestinal symptoms are severe enough to affect your daily activities or nutritional intake

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Communication with the prescribing clinician is essential before making any dose adjustments, as this may affect glycemic control or weight management outcomes

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