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While the results of STEP-HFpEF have generated enthusiasm in the cardiovascular community, it is important to consider the potential inadvertent consequence of substantial weight loss in a subpopulation at risk for malnutrition and sarcopenia (the reduction in skeletal muscle mass, and poor muscle strength and/or function)

Adults: Take 4 capsules per day, with juice or water, between meals or as directed by your qualified healthcare consultant

Mechanisms in endocrinology: the crosstalk between thyroid gland and adipose tissue: signal integration in health and disease

The 2.4 mg weekly maintenance dose is where the phase 3 monotherapy trials showed the strongest results, with an average body weight reduction of 11.8% over 68 weeks