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Fukuyama Y, Miyao M, Ishizu T, Maruyama H

Histamine : Causes blood vessel dilation, increased mucus production, and itching Prostaglandins (particularly PGD2) : Contribute to inflammation in airways Leukotrienes : Potent contributors to airway constriction (LTC4, LTD4, LTE4) Cytokines : Signal other immune cells to join the response (IL-4, IL-5, IL-6, IL-13) Tryptase : Promotes inflammation and tissue remodeling This is why blocking just one pathway like antihistamines do often isn't enough

10.1016/j.bbalip.2016.02.014 20 HeijmanJ.DobrevD

The logic behind combining Cagrilintide with a GLP-1 agonist is straightforward