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Due to its effect on ventral tegmental area (VTA) and striatal dopamine levels, it is suggested that both peripheral and central GLP-1 regulates hunger, satiety, and body weight (Kenny, 2011)

Patients may notice: Sunken cheeks and temples More prominent facial bones Loose or sagging skin While the term "Ozempic face" is not medically recognized, it highlights real cosmetic concerns tied to rapid fat loss

These studies showed that Januvia significantly lowers A1C levels when used alone or as add-on therapy with medications such as metformin, sulfonylureas, or insulin