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Molecular oxygen is a primary destabilizing factor for both senkyunolide A and I, with light and heat further promoting their breakdown under aerobic conditions (121)

These may include: Managing diabetes and high blood pressure Quitting smoking Maintaining a healthy weight Eating a balanced, low-sodium diet Staying physically active Your doctor may prescribe medications to help manage your kidney disease, such as: ACE inhibitors or ARBs to control blood pressure and reduce protein in urine Diuretics to help remove excess fluid Erythropoiesis-stimulating agents to treat anemia Phosphate binders to control phosphorus levels If your kidneys are no longer able to filter waste and excess fluid effectively, you may need dialysis

If you are taking pioglitazone with insulin, inform your doctor immediately if you develop symptoms such as shortness of breath or swelling, as this combination may increase the risk of heart failure in some people

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