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If there has been long-standing damage, this triggering might overwhelm the system, temporarily worsening symptoms

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require documentation of indication, dosing, and clinical response Biologics (IL-12/23 inhibitor): Ustekinumab (Stelara, J3357) FDA-approved for moderate-to-severe CD

Big Pharmas Role: Speculation about pharmaceutical companies influencing the FDAs decision highlights concerns about competition and access to new treatments