Eight more mutations (H18D, H21N, R167N, K168A, D171S, K172R, E174S, and I179T) were introduced at binding site 1 on the molecule to prevent PEGylation and to increase the affinity for the receptor at this site
The idea is to layer, not to mix vigorously on the skin
Antioxidants are substances that can prevent damage to cells caused by free radicals, potentially harmful molecules that the body produces as a reaction to environmental and other pressures
Also, a similar protocol was successful in the therapy of the other fistulas, that is, gastrocutaneous (Skorjanec et al., 2009), esophagocutaneous (Cesarec et al., 2013), duodenocutaneous (Skorjanec et al., 2015), vesicovaginal (Grgic et al., 2016), and rectovaginal (Baric et al., 2016) in rats