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A recent systematic review and meta-analysis of 21 randomized, placebo-controlled trials examining the effect of B-vitamin supplementation found the supplementation decreased homocysteine concentrations and improved measures global cognitive function but had no effect on individual measures of executive function, information processing speed, or episodic memory (89)

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The risks associated with vitamin B12 deficiency include fatigue, weakness, tingling or numbness in the hands and feet, difficulty walking, and anemia