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Comparative effectiveness of canagliflozin, SGLT2 inhibitors and non-SGLT2 inhibitors on the risk of hospitalization for heart failure and amputation in patients with type 2 diabetes mellitus: a real-world meta-analysis of 4 observational databases (OBSERVE-4D)

Such an alteration may strengthen G protein coupling by introducing several newly formed polar interactions such as two salt bridges (R176 2.46b and E408 8.49b , E423 8.64b and R46 in G)

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