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PR3-ANCA bind and cross-link mPR3 (137) on neutrophils, thereby initiating, together with Fc receptor engagements (138, 139), intracellular mitogen-activated protein kinase (140), Syk tyrosine kinase (141), and phosphoinositide 3-kinase/Akt (142, 143), signaling and subsequently cell activation

Reconstitute only under controlled laboratory conditions using appropriate technique

Here's what the science says, and why it deserves a place in your routine

It is one of the most-studied compounds in dermatology and matrix-biology research literature, frequently referenced in pre-clinical models of extracellular-matrix remodelling and gene-expression studies