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Upregulation of the Nrf2 pathway by sulforaphane also attenuated oxidative damage-induced vascular endothelial cell injury in a mouse model of type 2 diabetes mellitus (14)

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7 Tight junctions, which are functional barriers created by joining together endothelial cells, are made up of cytoplasmic accessory proteins (zona occludens-1, -2, and -3), which anchor the actin cytoskeleton to transmembrane proteins (claudins and occludin)

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