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At year 1, superior weight loss with liraglutide (7.8 kg) over both placebo (2.0 kg) and orlistat (3.9 kg) was demonstrated

Possible side effects of Ozempic (semaglutide) injection, Novo Nordisk Once-weekly Ozempic (semaglutide) injection mechanism of action, Novo Nordisk Rapid weight loss can lead to loss of muscle mass, UCLA Health (2024) Safety profile for once-weekly Ozempic (semaglutide) injection, Novo Nordisk Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

Asian J Sports Med 5, 123128

These results taken together suggest that adding even mild amounts of GR agonism (to increase energy expenditure) on top of a dual agonist like Tirzepatide is able to produce even more pronounced decreases in weight