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Similarly, a 2023 study published in the Journal of the American Medical Association (JAMA) found that individuals taking GLP-1 drugs were more than four times as likely to experience bowel obstruction compared with patients using bupropion-naltrexone, another class of weight-management medication

Nature 511 , 478482 (2014)

If reduced genital blood flow is the primary issue, PDE-5 inhibitors (the same class of medications that includes sildenafil) could theoretically help by increasing blood flow to genital tissue

acylcarnitines with highly polyunsaturated components are less cardiotoxic than are saturated and monounsaturated analogues