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The use of exendin-4 in old OVX rats increased the serum levels of several bone formation markers, including ALP, OC, and N-terminal propeptide of type I procollagen (P1NP) ( GLP-1 Promotes Bone Formation by Lowering Glucose Level It was indicated that hyperglycemia was negatively associated with lumbar BMD ( The Expression of GLP-1 Receptor on the Osteoblast Function It has been established that GLP-1 is involved in important physiological processes through binding to the GLP-1 receptor, which is a cAMP-linked G protein-coupled receptor found in the pancreas and many extra pancreatic tissues

Some doctors explore dual-therapy approaches in complex cases, but starting monotherapy with the most effective single agent is standard practice

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